Auto-Inflammatory Syndromes

Auto-inflammatory syndromes, sometimes called periodic fever syndromes, include a wide range of rare diseases in which the body has difficulty controlling inflammation. Some of the more common syndromes include periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome; familial Mediterranean fever (FMF); and tumor necrosis factor receptor-associated periodic syndrome (TRAPS).  

Causes and Symptoms

Genetic factors are thought to contribute to auto-inflammatory syndromes. Occasionally, an environmental trigger or infection may cause the disease. Symptoms include regular fevers, joint pain, rash, sores in the mouth, enlarged glands and abdominal pain, depending on the specific condition.

Diagnosis

Many auto-inflammatory syndromes are diagnosed based on a combination of signs, symptoms and abnormal lab results. The first step is to rule out other causes of recurrent fever, such as infection or an autoimmune disease. Additional diagnostics may include a physical exam, genetic tests and blood and urine tests.

Treatment

The type of treatment recommended will depend on your child’s diagnosis. There is no cure for auto-inflammatory syndromes. The main goal is to prevent fever and other symptoms. Some syndromes require long-term care management, while others will resolve as your child grows. Our team will visit with you and your child about an effective treatment plan specific to his or her unique needs.

Please call us at 512-494-4000 to learn more about auto-inflammatory syndromes or schedule an appointment.